The 2026 NFL scouting combine begins next Monday in Indianapolis, where Lions GM Brad Holmes and head coach Dan Campbell will evaluate prospects. Mesidor, a 6-foot-3, 265-pound edge rusher, recorded 63 tackles, 12.5 sacks and four forced fumbles last season.
He excelled in pressure moments, registering 5.5 sacks during Miami's College Football Playoff run. The 25-year-old would complement All-Pro pass-rusher Aidan Hutchinson, giving Detroit a formidable edge-rushing duo. Daniel Jeremiah also mocked Mesidor to Detroit at the end of January.