The Boilermakers produced their highest point total in the series since 1998 and their largest margin since 1969. Fletcher Loyer and Omer Mayer each added 18 points as Purdue (22-5, 12-4 Big Ten) took control early and led wire to wire.
Lamar Wilkerson scored 18 of his 20 points in the second half for Indiana (17-10, 9-7), which lost its second straight to a top-10 team.